高良姜素|548-83-4

【中文名】：高良姜素
【CAS号】：548-83-4
【英文名】：3,5,7-Trihydroxyflavone
【别名】：3,5,7-三羟基黄酮;高良姜精
【分子式】：C15H10O5
【分子量】：270.24
【干燥失重】：≤2%
【用途】：本品仅用于实验室科研含量测定。
【检测方式】：高效液相色谱法HPLC≥98%
【分析方法】: HPLC-DAD or/and HPLC-ELSD
【贮  存】：密封避光，2-8℃保存。
【供   货】：可根据客户需要包装、定制、批量生产！
数据库:548-83-4(CASDataBaseReference)
用途高良姜是一种在高良姜、高良姜和蜂胶中发现的黄烷类物质。高良姜已被证明可以抑制雌激素受体阳性的MCF-7人乳腺癌细胞的增殖，并延缓乳腺肿瘤的发生。生物活性Galangin(Norizalpinin)是arylhydrocarbon受体的调节剂，同时抑制CYP1A1的活性。体外研究Galangin(Norizalpinin)inhibitsthecatabolicbreakdownofDMBA,asmeasuredbythin-layerchromatography,inadose-dependentmanner.GalanginalsoinhibitstheformationofDMBA-DNAadducts,andpreventsDMBA-inducedinhibitionofcellgrowth.Galangincausesapotent,dose-dependentinhibitionofCYP1A1activity,asmeasuredbyethoxyresorufin-O-deethylaseactivity,inintactcellsandinmicrosomesisolatedfromDMBA-treatedcells.Analysisoftheinhibitionkineticsbydouble-reciprocalplotdemonstratesthatgalangininhibitsCYP1A1activityinanoncompetitivemanner.GalangincausesanincreaseinthelevelofCYP1A1mRNA,indicatingthatitmaybeanagonistofthearylhydrocarbonreceptor,butitinhibitstheinductionofCChemicalbookYP1A1mRNAbyDMBAorby2,3,5,7-tetrachlorodibenzo-p-dioxin(TCDD).GalanginalsoinhibitstheDMBA-orTCDD-inducedtranscriptionofareportervectorcontainingtheCYP1A1promoter.Galangintreatmentinhibitscellproliferationandinducedautophagy(130μM)andapoptosis(370μM).Inparticular,galangintreatmentinHepG2cellscauses(1)anaccumulationofautophagosomes,(2)elevatedlevelsofmicrotubule-associatedproteinlightchain3,and(3)anincreasedpercentageofcellswithvacuoles.p53expressionisalsoincreased.Thegalangin-inducedautophagyisattenuatedbytheinhibitionofp53inHepG2cells,andoverexpressionofp53inHep3Bcellsrestoredthegalangin-inducedhigherpercentageofcellswithvacuolestonormallevel.化学性质淡黄色结晶粉末，易溶于乙醇、乙醚，来源于姜科植物高良姜（AlpiniaofficinarumHance）根。
用途高良姜素具有抗病毒，镇痛，止呕的作用。用途用于含量测定/鉴定/药理实验等。
药理药效:具有抗病毒作用，能使鼠伤寒沙门氏菌TA98和TA100发生诱变。